Research
Our lab is mainly interested in parasitic worms (helminths) that cause pronounced diseases to humans and animals. Many of the human diseases are termed Neglected Tropical Diseases, because they infect hundreds of millions of people in tropical regions but are sadly overlooked by R&D efforts in developed countries.
People
I am recruiting undergraduate researchers for the fall and spring terms, as well as Winterim and Summer REU programs.
Potential projects include:
- Establishing new innovate behavioral assays by designing and implementing a custom imaging platform (📷 Cameras! 🤖 3D printing! 🪱 Worms!)
- Engineering software to track and extract features from videos of moving animals ( 🖥️ Computers! 🐍 Python!)
- Deciphering how parasites are able to find snails (🧠 Behaviors! 🐌 Animals!)
- Surveying the intestinal parasite community of California ground squirrels (💩 Poop! 🐿️ Squirrels!)
Publications
- 2023
- NJ Wheeler, KT Ryan, KJ Gallo, CR Henthron, SS Ericksen, JD Chan, M Zamanian
- Communications Biology
Pharmacological profiling of a Brugia malayi muscarinic acetylcholine receptor as a putative antiparasitic target
- KJ Gallo, NJ Wheeler, AM Elmi, PM Airs, M Zamanian
- Antimicrobial Agents and Chemotherapy
- IK Kamara, JT Thao, K Kaur, NJ Wheeler, JD Chan
- microPublication Biology
Mapping resistance-associated anthelmintic interactions in the model nematode Caenorhabditis elegans
- EG Rehborg, NJ Wheeler, M Zamanian
- PLOS NTD
- LR Nunn, TG Juang, DJ Beebe, NJ Wheeler, M Zamanian
- Integrative Biology
- KT Ryan, NJ Wheeler, IK Kamara, H Johnson, JE Humphries, M Zamanian, JD Chan
- Antimicrobial Agents and Chemotherapy
Extracellular vesicles secreted by Brugia malayi microfilariae modulate the melanization pathway in the mosquito host
- HJ Loghry, H Kwon, RC Smith, NA Sondjaja, SJ Minkler, S Young, NJ Wheeler, M Zamanian, LC Bartholomay, MJ Kimber
- Scientific Reports
- 2022
- NJ Wheeler, EA Hallem, M Zamanian
- Trends in Parasitology
- PM Airs, K Vaccaro, KJ Gallo, N Dinguirard, ZW Heimark, NJ Wheeler, J He, K Weiss, NE Schroeder, J Huisken, M Zamanian
- PLOS Pathogens
- 2020
- HJ Loghry, W Yuan, M Zamanian, NJ Wheeler, TA Day, MJ Kimber
- Journal of Extracellular Vesicles
- NJ Wheeler, PM Airs, M Zamanian
- PLOS Neglected Tropical Diseases
- NJ Wheeler, ZW Heimark, PM Airs, A Mann, LC Bartholomay, M Zamanian
- PLOS Biology
- 2019
- T Maier, NJ Wheeler, EKO Namigai, J Tycko, RE Grewelle, Y Woldeamanuel, K Klohe, J Perez-Saez, SH Sokolow, GA De Leo, TP Yoshino, M Zamanian, J Reinhard-Rupp
- PLOS Neglected Tropical Diseases
- International Helminth Genomes Consortium
- Nature Genetics
- 2018 and earlier
- NJ Wheeler, N Dinguirard, J Marquez, A Gonzalez, M Zamanian, TP Yoshino, MG Castillo
- Parasites & Vectors
- S Hahnel, NJ Wheeler, Z Lu, A Wangwiwatsin, P McVeigh, A Maule, M Berriman, TA Day, P Ribeiro, CG Grevelding
- PLOS Pathogens
- NJ Wheeler, PN Agbedanu, MJ Kimber, P Ribeiro, TA Day, M Zamanian
- Parasites & Vectors
- M Zamanian, PN Agbedanu, NJ Wheeler, P McVeigh, MJ Kimber, TA Day
- PLOS One
Lab protocols
| Name | Created | Status | Category |
|---|---|---|---|
Jun 7, 2022 8:38 PM | Complete | SchistosomesSnailsRecipes | |
Jun 7, 2022 8:38 PM | Not started | SchistosomesSnailsLab tasksMolecular biologyRecipes | |
Jun 7, 2022 8:38 PM | Complete | Schistosomes | |
Jun 7, 2022 8:38 PM | In progress | SchistosomesSnails | |
Jun 7, 2022 8:38 PM | Complete | SnailsSchistosomes | |
Mar 13, 2023 3:34 PM | Complete | Parasitology | |
May 19, 2023 2:55 PM | In progress | Molecular biology | |
Jul 17, 2023 2:07 PM | Complete | Bioinformatics | |
Jul 17, 2023 2:30 PM | In progress | Bioinformatics | |
Jul 18, 2023 7:37 PM | In progress | Bioinformatics | |
Aug 1, 2023 2:40 PM | In progress | Imaging | |
Aug 30, 2023 5:26 PM | Complete | Molecular biology |