Wheeler Lab @ UW-Eau Claire

Advancing knowledge and equity in parasitology

🐌 Host – parasite interactions 🪱

🧬 Molecular biology

🖥 Bioinformatics

📊 Data visualization

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👨🏼‍🏫 Teaching

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🧬 Research

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📜 CV

📰 News

January 2023 - The final chemogenomic screening manuscript is published in Communications Biology.

Multivariate chemogenomic screening prioritizes new macrofilaricidal leads - Communications Biology

Development of direct acting macrofilaricides for the treatment of human filariases is hampered by limitations in screening throughput imposed by the parasite life cycle. In vitro adult screens typically assess single phenotypes without prior enrichment for chemicals with antifilarial potential.

www.nature.com

Multivariate chemogenomic screening prioritizes new macrofilaricidal leads - Communications Biology

November 2022 - The final wrmXpress manuscript is published in PLOS NTD.

wrmXpress: A modular package for high-throughput image analysis of parasitic and free-living worms

Author summary Advances in automated microscopy have led to the proliferation of high-throughput experimental techniques to screen drugs for activity against parasitic worms, which infect billions of people around the world.

journals.plos.org

wrmXpress: A modular package for high-throughput image analysis of parasitic and free-living worms

August 2022 - Our review with the Zamanian (UW-Madison) and Hallem (UCLA) labs is published in Trends in Parasitology.

Making sense of sensory behaviors in vector-borne helminths

Migrations performed by helminths are impressive and diverse, and accumulating evidence shows that many are controlled by sophisticated sensory progra...

www.sciencedirect.com

Making sense of sensory behaviors in vector-borne helminths

July 2022 - New preprint on multivariate screening for macrofilaricide discovery.

July 2022 - See you at ASP! Nic will be traveling to College Station for the American Society of Parasitologists annual meeting. He’ll be giving a talk in the Genomics & Molecular Biology session on Monday afternoon, July 11. Slides are available at asp2022.wheelerlab.bio