Created
Jan 24, 2023 3:55 PM
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Abstract
Development of direct acting macrofilaricides for the treatment of human filariases is hampered by limitations in screening throughput imposed by the parasite life cycle. In vitro adult screens typically assess single phenotypes without prior enrichment for chemicals with antifilarial potential.
Link
https://www.nature.com/articles/s42003-023-04435-8
Multivariate chemogenomic screening prioritizes new macrofilaricidal leads
Communications Biology - A comprehensive optimization of phenotypic and computational screening strategy for antifilarial drug and target discovery identifies compounds with stage, species, and/or...
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