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    Multivariate chemogenomic screening prioritizes new macrofilaricidal leads

    Multivariate chemogenomic screening prioritizes new macrofilaricidal leads

    Created
    Jan 24, 2023 3:55 PM
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    Abstract

    Development of direct acting macrofilaricides for the treatment of human filariases is hampered by limitations in screening throughput imposed by the parasite life cycle. In vitro adult screens typically assess single phenotypes without prior enrichment for chemicals with antifilarial potential.

    Link
    https://www.nature.com/articles/s42003-023-04435-8
    Multivariate chemogenomic screening prioritizes new macrofilaricidal leads

    Communications Biology - A comprehensive optimization of phenotypic and computational screening strategy for antifilarial drug and target discovery identifies compounds with stage, species, and/or...

    www.nature.com

    Multivariate chemogenomic screening prioritizes new macrofilaricidal leads
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